Experiments were conducted to evaluate PRE and POST cotton herbicides for control of MSMA-resistant (R) and -susceptible (S) common cocklebur biotypes, and to determine potential cross-resistance of the R biotype to other arsenical and membrane disruptor herbicides. Cyanazine and clomazone applied PRE were the most effective herbicides for control of R populations. Lactofen or cyanazine in combination with MSMA controlled R and S biotypes better than fluometuron or pyrithiobac combined with MSMA. MSMA-resistant common cocklebur was not cross-resistant to other arsenical herbicides. Significant differences in cellular electrolyte leakage and chlorophyll content of the treated leaf between biotypes were not evident for paraquat, acifluorfen, and MSMA.